Αποτελέσματα Αναζήτησης
19 Μαρ 2024 · Objectives: Assess the diverse mechanisms through which valproic acid exerts its therapeutic effects across various medical conditions. Analyze the evidence supporting the use of valproic acid in specific patient populations, such as pediatric patients, pregnant women, and older individuals.
Valproic acid (VPA) is a branched short-chain fatty acid derived from naturally occurring valeric acid. VPA is used primarily in the treatment of epilepsy and seizures, but is also used in migraine, bipolar, mood, anxiety, and psychiatric disorders [1].
Population pharmacokinetics is an essential tool that helps guide individualized dosing regimens. The aims of this systematic review are to provide knowledge concerning population pharmacokinetics of valproic acid (VPA) and to identify factors influencing VPA pharmacokinetic variability.
19 Μαρ 2024 · Valproic acid (VPA) ia as a highly prevalent medication with multifaceted therapeutic applications in various neurological and psychiatric disorders. The therapeutic uses of VPA include epilepsy treatment across different seizure types, bipolar disorder management, and migraine prophylaxis.
The aim of this review is to analyze both clinical and preclinical aspects regarding the use of valproic acid (N-dipropylacetic acid or VPA), moving from preclinical evidences of anticonvulsant activity and neuroprotection to clinical data on efficacy and tolerability profile both in the pediatric and adult population.
16 Ιαν 2003 · Valproic acid is a short branched fatty acid used as an anticonvulsant drug whose therapeutic action has been proposed to arise from membrane-disordering properties. Static and kinetic properties of valproic acid interacting with fully hydrated dipalmitoyl phosphatidylcholine lipid bilayers are studied using molecular-dynamics simulations.
Intravenous valproic acid lends itself well to a continuous infusion as it exhibits a relatively short half-life. We evaluated the pharmacokinetics and clinical efficacy of continuous infusion valproic acid in hospitalized patients with migraine and seizures.
