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  1. 10 Αυγ 2020 · Uracil may arise in DNA as a result of spontaneous cytosine deamination and/or misincorporation of dUMP during DNA replication. In this paper we will review: (i) sources of the origin of uracil in DNA; (ii) some properties of the enzymes responsible for the excision of uracil and their role in the I ….

  2. 16 Δεκ 2002 · UNG2 is a major nuclear uracil-DNA glycosylase central in removal of misincorporated dUMP in replication foci, but recent evidence also indicates an important role in repair of U : G mispairs...

  3. patch pathway, which largely use different proteins. UNG2 is a major nuclear uracil-DNA glycosylase central in removal of misincorporated dUMP in replication foci, but recent evidence also...

  4. 3 Μαρ 2009 · Uracil in DNA may result from incorporation of dUMP during replication and from spontaneous or enzymatic deamination of cytosine, resulting in U:A pairs or U:G mismatches, respectively. Uracil generated by activation-induced cytosine deaminase (AID) in B cells is a normal intermediate in adaptive immunity.

  5. 1 Δεκ 2010 · Uracil existing in DNA may arise as a result of spontaneous deamination of cytosine (leading to U:G mispairing) or from incorporation of dUMP during replication in place of dTMP leading to U:A pairing.

  6. The lower panel lists the specific DNA repair pathways that are instigated to repair DNA damages: mismatch repair corrects replication errors and other base mismatches; base excision repair removes base adducts, uracil, abasic sites and oxidative lesions; single strand break repair pathways repairs single stranded breaks in the DNA backbone ...

  7. 1 Δεκ 2010 · Uracil existing in DNA may arise as a result of spontaneous deamination of cytosine (leading to U:G mispairing) or from incorporation of dUMP during replication in place of dTMP leading to U:A pairing.

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