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16 Δεκ 2002 · Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair.
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9 Σεπ 2008 · Increased uracil in DNA is observed under conditions of TLS (Figure 2). In humans, a significant inverse correlation was reported between uracil misincorporation in lymphocyte DNA and red blood cell folate [ 6 ].
28 Σεπ 2010 · Uracil (U) can be found in DNA as a mismatch paired either to adenine (A) or to guanine (G). Removal of U from DNA is performed by a class of enzymes known as uracil–DNA–glycosylases (UDG). Recent studies suggest that recognition of U–A and U–G mismatches by UDG takes place via an extra-helical mechanism.
1 Ιαν 2003 · UNG2 is a major nuclear uracil-DNA glycosylase central in removal of misincorporated dUMP in replication foci, but recent evidence also indicates an important role in repair of U : G mispairs...
16 Δεκ 2002 · Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair.
1 Δεκ 2010 · Uracil existing in DNA may arise as a result of spontaneous deamination of cytosine (leading to U:G mispairing) or from incorporation of dUMP during replication in place of dTMP leading to U:A pairing.
first uracil-DNA glycosylases recog-nise the uracil, and cut it out of the DNA. Then several enzymes con-tribute to the elimination and re-synthesis of the damaged part of DNA, during which the abasic (‘emp-ty’) site in the DNA is replaced with a cytosine (see Figure 6). However, the most common form of uracil-DNA glycosylase cannot tell
