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1. www.nature.com › articles › s41392/024/01868-3Targeting cytokine and chemokine signaling pathways for cancer...

   www.nature.com › articles › s41392/024/01868-3

   22 Ιουλ 2024 · Cytokines are critical in regulating immune responses and cellular behavior, playing dual roles in both normal physiology and the pathology of diseases such as cancer.

2. www.nature.com › articles › s41392/024/01856-7Exploring treatment options in cancer: tumor treatment strategies...

   www.nature.com › articles › s41392/024/01856-7

   17 Ιουλ 2024 · HER2 is the most prominent target for ADC development globally, and Ado-trastuzumab emtansine (Kadcyla), Trastuzumab deruxtecan (Enhertu), and Trastuzumab emtansine (T-DM1), which are designed to...

3. www.nature.com › articles › s41570/018/0044-4Methods for detection of cytosine and thymine modifications in...

   www.nature.com › articles › s41570/018/0044-4

   12 Οκτ 2018 · In this Review, we introduce the biochemistry of cytosine and thymine modifications and discuss established detection methods, such as bisulfite sequencing and its modifications, as well as newer...

4. www.ncbi.nlm.nih.gov › pmc › articlesThe interaction between cytosine methylation and processes of DNA...

   www.ncbi.nlm.nih.gov › pmc › articles

   7 Ιουλ 2017 · Finally, using multivariable regression models, we demonstrate that different cancers exhibit distinct mutation–methylation associations, with DNA repair influencing such associations in certain cancer genomes.

5. cancerci.biomedcentral.com › articles › 10The common bisulfite-conversion-based techniques to analyze DNA...

   cancerci.biomedcentral.com › articles › 10

   • Αποθηκευμένο αντίγραφο

   9 Ιουλ 2024 · Numerous studies have concentrated on describing DNA methylation patterns as biomarkers for cancer diagnosis monitoring and predicting response to cancer therapy. Various techniques for detecting DNA methylation status in cancers are based on sodium bisulfite treatment.

6. www.ncbi.nlm.nih.gov › pmc › articlesEpigenetic Regulators of DNA Cytosine Modification: Promising...

   www.ncbi.nlm.nih.gov › pmc › articles

   21 Φεβ 2023 · In this review, we discuss the DNA methylation/demethylation pathway as a promising target for therapeutic intervention in cancer and highlight the development of various epigenetic drugs targeting DNA-modifying enzymes such as DNA methyltransferases (DNMTs) and ten-eleven translocation (TET) enzymes.

7. www.sciencedirect.com › science › articleLocked nucleic acid (LNA): A modern approach to cancer diagnosis...

   www.sciencedirect.com › science › article

   1 Φεβ 2023 · An LNA-DNA heteroduplex with fully complementary nucleotides has a higher Tm than a DNA-DNA duplex with a single base mismatch. A sensitive PCR method called peptide nucleic acid-locked nucleic acid (PNA-LNA) PCR clamp is a practical method for detecting EGFR mutations in lung cancer [ 108 , 109 ].