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26 Σεπ 2022 · Fomepizole is the antidote for toxic alcohols, and it acts by inhibiting alcohol dehydrogenase to cease toxic alcohol metabolism. Ethanol may also be utilized therapeutically to inhibit alcohol dehydrogenase when fomepizole is unavailable.
Fomepizole (Antizol) is a convenient antidotal therapy for treatment of ethylene glycol or methanol intoxication. Fomepizole received US Food and Drug Administration (FDA) approval for use in...
Both methanol (Me) and ethylene glycol (EG) are metabolized by the liver enzyme alcohol dehydrogenase (ADH) to toxic metabolites, which cause a profound metabolic acidosis, along with other serious toxic effects.
1 Σεπ 2002 · Ethylene glycol poisoning should be suspected in an intoxicated patient with anion gap acidosis, hypocalcemia, urinary crystals, and nontoxic blood alcohol concentration.
9 Νοε 2015 · Guidelines suggest that fomepizole should be the main antidote for methanol or ethylene glycol poisoning 37, 38, while ethanol can be used when fomepizole is unavailable.
17 Ιαν 2018 · Poisonings by the toxic alcohols (methanol, ethylene glycol, isopropanol, diethylene glycol, and propylene glycol) are potentially fatal. This review summarizes the mechanisms of...
10 Φεβ 2023 · The EXTRIP workgroup reviewed the available literature pertaining to the role of ECTR in ethylene glycol poisoning to propose treatment recommendations based on blood tests with and without the use of ADH blockers. The presence of kidney impairment decreased the thresholds for ECTR use.
