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  1. The 2025 edition of ICD-10-CM D57.2 became effective on October 1, 2024. This is the American ICD-10-CM version of D57.2 - other international versions of ICD-10 D57.2 may differ. One of the sickle cell disorders characterized by the presence of both hemoglobin s and hemoglobin c.

    • D57.40

      D57.40 is a billable/specific ICD-10-CM code that can be...

  2. Clinical Information. One of the sickle cell disorders characterized by the presence of both hemoglobin s and hemoglobin c. It is similar to, but less severe than sickle cell anemia. ICD-10-CM D57.20 is grouped within Diagnostic Related Group (s) (MS-DRG v42.0): 811 Red blood cell disorders with mcc. 812 Red blood cell disorders without mcc.

  3. Haemoglobin SC disease is a sickling disorder which results from the co-inheritance of two abnormal ß globin genes, haemoglobin S and haemoglobin C (ß s ß c). It is characterised by the presence of SC poikilocytes, abnormally contracted cells which resemble sickle cells but which have straight edges or are branched.

  4. Hemoglobin S-C disease is suspected in patients whose clinical features suggest sickle cell disease or whose red blood cells demonstrate sickling. Stained blood smears show target cells, spherocytes, and rarely sickle cells or oat-shaped cells.

  5. People with this disease have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape. Signs and symptoms of sickle cell disease usually begin in early childhood.

  6. Hemoglobin C, S-C, and E diseases are inherited conditions characterized by gene mutations that affect the hemoglobin (the protein that carries oxygen) in red blood cells. These red blood cells are destroyed more quickly than others, resulting in chronic anemia.

  7. Clinical features. Hb SC disease usually results in a milder form of SCD, but it can be severe in some cases. Growth and development are delayed compared with normal children. Unlike Hb SS, Hb SC usually does not produce significant symptoms until the teenage years.

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