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In this review, we summarize the recent epidemiological, experimental, and clinical findings of zinc dyshomeostasis in cancer, and outline the potential clinical applications of zinc in cancer prevention, diagnosis, and therapy.
- Zinc in cancer prevention - PubMed
Zinc inhibits NF-kappa B via induction of A-20. Thus, zinc...
- Zinc: A promising agent in dietary chemoprevention of cancer
Zinc exerts a positive beneficial effect against chemically...
- Zinc in cancer prevention - PubMed
26 Ιαν 2021 · With respect to cancer, several in vitro and in vivo studies point to beneficial effects via the immune system by activating macrophages. Zinc modulates oxidative stress and might help to prevent cancer [7]. In case reports, an improvement of the effects of chemotherapy has been described [8].
Zinc inhibits NF-kappa B via induction of A-20. Thus, zinc supplementation should have beneficial effects on cancer by decreasing angiogenesis and induction of inflammatory cytokines while increasing apoptosis in cancer cells.
Zinc exerts a positive beneficial effect against chemically induced preneoplastic progression in rats and provides an effective dietary chemopreventive approach to disease in vulnerable section of population with family history of carcinoma.
2 Σεπ 2023 · Clinically, it would be beneficial to explore the relationship between serum zinc levels and local zinc concentrations in patients with cancer, as well as the reliability of serum zinc levels as a biomarker of carcinogenesis risk and cancer patient prognosis.
In this review, we intend to analyze the current available research data and epidemiological and clinical evidence on the role of zinc in human cancer prevention and treatment. We focus on the cancers – prostate, breast, and pancreatic – for which the most basic and epidemiological studies with zinc have been carried out.
The patients treated with zinc were mainly diagnosed with head and neck cancer and underwent chemo-, radio- or concurrent radio-chemotherapy. Interventions included the intake of different amounts of zinc supplements and oral zinc rinses.
