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11 Δεκ 2022 · Zinc is an important cofactor in the body and is essential for normal function; however, increased levels of zinc can become toxic. Three types of exposure can lead to toxicity: inhalation, oral, and dermal.
Toxicity is rare. Ingesting doses of elemental zinc ranging from 100 to 150 mg/day for prolonged periods interferes with copper metabolism and causes low blood copper levels, red blood cell microcytosis, neutropenia, and impaired immunity; higher doses should be given only for short periods of time and the patient followed closely.
This chapter contains a description of the toxic effects that have been associated with exposures to high levels of zinc and selected zinc compounds by the inhalation, oral, and dermal routes. Specifically, zinc chloride, zinc oxide, zinc sulfate, and zinc sulfide will be discussed.
1 Ιουλ 2024 · The European Food Safety Authority (EFSA) defines the tolerable upper intake level (UL) as 25 mg per day, whereas the Food and Drug Administration (FDA) allows 40 mg per day. This review will summarize the current knowledge regarding the calculation of UL and other health risks associated with zinc.
Zinc deficiency is frequent in the elderly and leads to changes similar to those that occur in oxidative inflammatory aging (oxi-inflamm-aging) and immunosenescence. The possible benefits of zinc supplementation to enhance immune function are discussed. Keywords: zinc, aging, immunosenescence.
Ingesting doses of elemental zinc ranging from 100 to 150 mg/day for prolonged periods interferes with copper metabolism and causes low blood copper levels, red blood cell microcytosis, neutropenia, and impaired immunity; higher doses should be given only for short periods of time and the patient followed closely.
In healthy people, the amount of zinc in serum or plasma is 80 to 120 mcg/dL (12 to 18 mcmol/L) [2]. Serum zinc levels below 70 mcg/dL in women and 74 mcg/dL in men indicate inadequate zinc status. However, both serum and plasma measures have important limitations.
