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1 Ιουλ 2017 · Under anaerobic conditions, glycolysis produces minimal energy in the form of ATP. This mode of glycolysis is not coupled to the TCA cycle and oxidative phosphorylation. However, under aerobic conditions, glycolysis, TCA cycle activity, and oxidative phosphorylation generate considerable energy for cellular functions.
- The Warburg and Crabtree Effects
Yeast shares with cancer cells the metabolic features that...
- Hypoxia-Inducible Factor 1
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor...
- Regulation of Cellular Energy Metabolism. The Crabtree Effect
The second of these is characteristic of aerobic organisms...
- Hif-1, O2, and The 3 PHDs
In the animal kingdom, the transcriptional activator...
- ATP Citrate Lyase Inhibition Can Suppress Tumor Cell Growth
The sensitivity profile of human cancer cell lines to ACL...
- Tigar, a p53-Inducible Regulator of Glycolysis and Apoptosis
The TIGAR gene is located on chromosome 12p13-3 and contains...
- The Warburg and Crabtree Effects
In this review, we have outlined the regulatory mode of glycolysis in cancer cells and presented the regulatory mechanism of GLUT, HK, PFK, PK, LDH, and other transporters or metabolic enzymes as targets in cancers and developed target drugs.
The second part of the review discusses aerobic glycolysis, or the Warburg effect, and the metabolic reprogramming involving glycolysis, tricarboxylic acid cycle, and glutaminolysis in the context of developing targeted inhibitors in cancer cells.
31 Ιουλ 2023 · Anaerobic glycolysis serves as a means of energy production in cells that cannot produce adequate energy through oxidative phosphorylation. In poorly oxygenated tissue, glycolysis produces 2 ATP by shunting pyruvate away from mitochondria and through the lactate dehydrogenase reaction.
28 Σεπ 2024 · In this review, we first summarize the role of the glycolytic pathway in cancer cells and their TME in relation to tumorigenesis. Further, we review the role of small molecules targeting the glycolytic pathway for potential cancer therapeutic strategies.
Although aerobic glycolysis is often found in malignant tumors, OXPHOS still contributes to energy production in cancers, and may play a major role in energy production in some cancers . This article reviews the roles of glycolysis and OXPHOS in the energy metabolism of cancers.
3 Δεκ 2013 · Although glycolysis is less efficient than oxidative phosphorylation in the net yield of adenosine triphosphate (ATP), cancer cells adapt to this mathematical disadvantage by increased glucose up-take, which in turn facilitates a higher rate of glycolysis.
