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Two distinct coagulase-dependent barriers protect Staphylococcus aureus from neutrophils in a three dimensional in vitro infection model. PLoS pathogens. 2012;8:e1002434. doi: 10.1371/journal.ppat.1002434.
- Staphylococcus aureus Secretes Coagulase and von Willebrand Factor ...
Clinical isolates of Staphylococcus aureus secrete...
- Staphylococcus - Medical Microbiology - NCBI Bookshelf
Bacteria in the genus Staphylococcus are pathogens of man...
- Coagulase Activity by Staphylococcus aureus: A Potential ... - PubMed
Here, we review how the manipulation of the host's...
- Staphylococcus aureus Secretes Coagulase and von Willebrand Factor ...
S. aureus uses coagulase to form a fibrin coat from fibrinogen present in the bloodstream. This helps the bacteria evade detection and phagocytosis by the immune system. Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin.
Clinical isolates of Staphylococcus aureus secrete coagulases, polypeptides that bind to and activate prothrombin, thereby converting fibrinogen to fibrin and promoting the clotting of plasma or blood.
5 Αυγ 2010 · Clinical isolates of the human pathogen Staphylococcus aureus secrete coagulase (Coa), a polypeptide that binds to and activates prothrombin, thereby converting fibrinogen to fibrin and promoting clotting of plasma or blood. Another secreted coagulase, designated von-Willebrand factor binding protein (vWbp), catalyzes a similar reaction.
Bacteria in the genus Staphylococcus are pathogens of man and other mammals. Traditionally they were divided into two groups on the basis of their ability to clot blood plasma (the coagulase reaction). The coagulase-positive staphylococci constitute the most pathogenic species S aureus.
1 Ιαν 2018 · Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infections
Here, we review how the manipulation of the host's hemostatic system contributes to the disease-causing potential of S. aureus and discuss the S. aureus coagulases as promising targets for novel therapeutic strategies.
