Αποτελέσματα Αναζήτησης
28 Οκτ 2021 · Endogenous cytoplasmic DNA (cytoDNA) species are emerging as key mediators of inflammation in diverse physiological and pathological contexts.
- PubMed
Cytoplasmic DNA is emerging as a pivotal contributor to the...
- PubMed
28 Οκτ 2021 · In this review, we focus on four species of endogenous cytoDNA: micronuclei, cytoplasmic chromatin fragments, mitochondrial DNA, and retrotransposons. We evaluate the major species of endogenous cytoDNA, illustrating the mechanisms involved in cytoDNA formation, functions, and pathologies.
30 Απρ 2021 · cGAS (also known as C6orf150, or male abnormal 21 domain containing 1 (MAB21D1)) is located on chromosome 6q13 and encodes a protein with 522 amino acids in human. Mechanistically, cGAS...
11 Απρ 2023 · Cytoplasmic DNA, both endogenous and exogenous, act as a danger signal to initiate the innate immune response in metazoan cells. Innate immunity is the first line against viral infection, and its conservative pattern maintains its resistance against viral revolution and variance.
26 Μαρ 2021 · Abstract. Accumulating evidence indicates the presence of cytoplasmic DNAs in various types of malignant cells, and its involvement in anti-cancer drug- or radiotherapy-mediated DNA damage ...
12 Απρ 2023 · Cytoplasmic DNA is emerging as a pivotal contributor to the pathogenesis of inflammatory diseases and cancer, such as COVID-19 and lung carcinoma.
28 Μαρ 2018 · Here, we show that cytoplasmic accumulation of nuclear DNA plays key roles in the onset of SASP. Although both DNase2 and TREX1 rapidly remove the cytoplasmic DNA fragments emanating from the...
