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17 Φεβ 2020 · Half-Life Elimination Normal hepatic function: Range: 8 to 37 hours; Immediate release: 18 hours; Extended release: 32 hours; Impaired hepatic function: 46.2 hours (range: 22.4 to 188 hours) (Winchell 2002)
8 Απρ 2024 · Flexeril has a long half life of between 1 and 3 days. This is the time it takes for your body to reduce the plasma drug levels by half. Flexeril is eliminated slowly from the body. It usually takes around 5.5 x half-life for a drug to be eliminated from your system.
The effective half-life of cyclobenzaprine in young healthy subjects is approximately 18 hours. 8,15,16 These values are extended in the elderly and those with hepatic insufficiency, with a mean effective half-life of 33.4 hours and 46.2 hours in these groups, respectively. 8
half-life of 18 hours (range 8-37 hours; n=18); plasma clearance is 0.7 L/min. The plasma concentration of cyclobenzaprine is generally higher in the elderly and in patients with hepatic...
27 Απρ 2020 · The FDA reports cyclobenzaprine’s half-life to be 18 hours with a range of 8-37 hours. For elderly people, however, cyclobenzaprine has a mean half-life of 33.4 hours and 46.2 hours for people with hepatic insufficiency.
Immediate-release tablet: 5 mg/day PO initially; titrate slowly upward and consider less frequent dosing. Extended-release capsule not recommended in elderly, because of increased plasma levels...
28 Αυγ 2023 · The mean elimination half-life for the immediate-release formulation is 18 hours(range 8 to 37 hours), and for the extended-release formulation is approximately 32 hours. Cyclobenzaprine is excreted predominantly as glucuronides via the kidney.
