Αποτελέσματα Αναζήτησης
30 Νοε 2012 · For our purposes, “ strong ” nucleophiles/bases are negatively charged and “ weak” nucleophiles/bases are neutral. A good rule of thumb is to expect SN2/E2 with “ strong ‘ (i.e. negatively charged) nucleophiles/bases and expect SN1/E1 with neutral nucleophiles/bases.
- The Solvent
I heard the explanation is that OH- is a good nucleophile...
- What Makes A Good Nucleophile?
“Sort the following nucleophiles by their veolcity in Sn2...
- The Solvent
16 Δεκ 2021 · Strong nucleophiles are required in S N 2 reactions, and strong nucleophile are usually negatively charged species, such as OH –, CH 3 O –, CN – etc. These anions must stay with cations in salt format like NaOH, CH 3 ONa etc.
24 Μαΐ 2021 · Therefore, SN2 is easier to perform for stronger nucleophiles. There are predictable periodic trends in nucleophilicity. More electronegative elements hold their electrons more tightly, and are less able to donate them to form a new bond.
18 Ιουν 2012 · “Sort the following nucleophiles by their veolcity in Sn2 reactions.” The correct answer is: F- < OH- < Cl- < CH3COO- < S-This makes no sense to me. That F- is slower than Cl- imakes sense, and that F- is slower than OH-, and that Cl- is slower than S-. But the other relationships don't make sense.
4 Δεκ 2012 · I heard the explanation is that OH- is a good nucleophile for an SN2 reaction, and when there’s alcohol and KOH the OH- can deprotonate the alcohol to get alkoxide ion, which is a stronger base than a nucleophile, so takes a proton for an E2 reaction.
Bimolecular nucleophilic substitution (S N 2) reactions are concerted, meaning they are a one step process. This means that the process whereby the nucleophile attacks and the leaving group leaves is simultaneous.
Triflate, tosylate and mesylate are the anions of strong acids. The weak conjugate bases are poor nucleophiles. Nucleophilicity increases in parallel with the base strength. Thus, amines, alcohols and alkoxides are very good nucleophiles.
