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The components involved in bone marrow histology are cortical and trabecular bone and stroma, vasculature, sinus wall layers, nerves, hematopoietic cells, and non-hematopoietic interstitial cells. Refer to Box 2 , Box 3 for a checklist and list of histochemical stains used to assess bone marrow histologic specimens.
- Laboratory Evaluation of Bone Marrow - StatPearls - NCBI Bookshelf
A comprehensive laboratory bone marrow examination includes...
- Laboratory Evaluation of Bone Marrow - StatPearls - NCBI Bookshelf
30 Οκτ 2023 · This article will review the embryology of the bone marrow as well as its histology. Additionally, the constituent cell lineages and their function will be discussed, together with clinically relevant processes and pathologies.
3 Μαρ 2024 · A comprehensive laboratory bone marrow examination includes a complete blood count (CBC) and analysis of the peripheral blood smear (PBS), bone marrow aspirate, core biopsy specimen, clot section, and cytometric flow.
Histopathology is a subjective assessment and is useful for evaluating bone marrow architecture, assessment of cellularity, estimation of M:E ratio (limited sensitivity), assessment of cell lineages, estimation of iron stores and other features (e.g., neoplasia, inflammation, pigment, infectious agents).
After patient preparation, sedation, and the procedure itself, a bone marrow investigation provides four specimen types for pathologist review (Figure 1): the bone marrow core biopsy, the bone marrow touch imprint, the bone marrow aspirate smear, and the bone marrow clot particle.
The bone marrow is best described as a unique semisolid organ which exists in a fine balance and has a dynamic relationship with lymphoid tissues and the peripheral blood. The main function of the marrow is production of haematopoietic cells which develop from a small group of self-propagating stem cells.
Describe the organization of the bone marrow and differentiate between bone marrow cords and sinuses. Recognize megakaryocyte cells and understand their function in platelet production.
