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1 Δεκ 2022 · The article highlights the story of neuroscientist John Sinclair and his discovery that prescribing naltrexone 1 hour before drinking improves drinking outcomes by decreasing the reward of and cravings for alcohol, which may be especially helpful for binge drinkers.
13 Δεκ 2001 · Although naltrexone, an opiate-receptor antagonist, has been approved by the Food and Drug Administration for the treatment of alcohol dependence, its efficacy is uncertain.
1 Ιαν 2001 · — Eight double-blind placebo-controlled clinical trials in five countries have demonstrated the safety and efficacy of naltrexone as an adjunct in alcoholism treatment. The efficacy depends, however, on how naltrexone is used.
The use of naltrexone targeted for use before drinking is popularly cred-ited to John David Sinclair, PhD (1943–2015), whose animal research showed that alcohol’s reinforcing effect could be blocked by naltrexone.
Key benefits of naltrexone include reductions in alcohol cravings and decreased relapse to heavy alcohol consumption, although such effects are modest [20,21,22]. However, these benefits may be undermined by poor medication adherence [ 17 , 23 ].
5 Σεπ 2012 · Oral naltrexone is relatively safe and has a moderate to good clinical efficacy in the management of persons with alcohol dependence [5, 6]. Meta-analysis studies have concluded that the use of naltrexone is most appropriate where controlled drinking is the desired outcome [7, 8].
14 Αυγ 2008 · Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo-pituitary-adrenocortical axis. Psychopharmacology (Berl)...
