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Pedigree Analysis (cf. chapters 4.4, 5.2, 6.2 of textbook) • “crosses” and “matings” in human(s) (families) are shown and analyzed in pedigrees – pedigrees are formalized ways using standard sets of symbols to depict family trees and lineages – pedigrees provide concise and accurate records of families
In this unit you shall learn about pedigree analysis and how to predict the most likely mode of inheritance and its applications. In addition the techniques used to disentangle the relative contribution of genes and environment will be discussed.
Pedigree analysis can be used to determine the mode of inheritance of a particular trait, allowing geneticists to begin to identify a gene (or genes) responsible. The mode of inheritance refers to how a trait is inherited: is it dominant or recessive?
Goals of Pedigree Analysis Determine the mode of inheritance: dominant, recessive, partial dominance, sex-linked, autosomal, mitochondrial, maternal effect. Predict the risk of disease in future offspring in a family (genetic counseling).
Pedigrees are diagrams that indicate the relationships among family members. They are used to identify dominant and recessive (and autosomal versus sex-linked) traits in humans. The affected individual through whom the pedigree is discovered is called the propositus. Some pedigree conventions (see Fig. 10.16, p. 272 for more symbols):
20 Ιουν 2023 · These diagrams are used to determine the mode of inheritance of a particular disease or trait, and to predict the probability of its appearance among offspring. Pedigree analysis is therefore an important tool in both basic research and genetic counseling.
Pedigree Analysis. 1. Pedigree charts. Pedigree charts are diagrams that show the pheno-types and/or genotypes for a particular organism, its ancestors, and descendants. While commonly used in human families to track genetic diseases, they can be used for any species and any inherited trait.
