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Figure. Dose–response curves for the beneficial and adverse effects of a drug. Prescribers will aim to prescribe doses that maximize benefits and minimize harms, which is easier for drugs where the ratio between the dose causing harm and that causing benefit (the ’therapeutic index’) is high.
The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose.
30 Ιουν 2015 · The therapeutic index is the ratio of the TD50 to the ED 50, a parameter which reflects the selectivity of a drug to elicit the desired effect rather than toxicity. The therapeutic window is the range between the minimum toxic dose and the minimum therapeutic dose, or the range of doses over which the drug is effective for most of the ...
22 Μαρ 2024 · The therapeutic index is defined as the ratio of the median lethal dose (LD50) to the median effective dose (ED50) of a drug. Formula for Therapeutic Index: TI = LD50/ED50. Where: LD50 is the median lethal dose (the dose that causes death in 50% of the test subjects).
The therapeutic index (ratio of the minimum toxic concentration to the median effective concentration) helps determine the efficacy and safety of a drug. Increasing the dose of a drug with a small therapeutic index increases the probability of toxicity and/or ineffectiveness of the drug.
The therapeutic index represents the relationship between concentrations causing adverse effects and concentrations causing desired effects. It is usually EC50 (adverse effect)/EC50 (desired effect) Drugs with a high or large therapeutic index are desirable in practice.
The therapeutic index of a drug is the ratio of the dose that produces toxicity to the dose that produces a clinically desired or effective response in a population of individuals. Where: TD50 is the dose of a drug that causes a toxic response in 50% of the population and ED50 is the dose of a drug that is therapeutically effective in 50% of ...
