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  1. XYREM® (sodium oxybate) is approved for use in adults and children ages 7 and older to help treat cataplexy and EDS in narcolepsy. See XYREM® prescribing information & BOXED Warning about serious side effects, CNS depression, misuse and abuse.

  2. JazzCares:1-833-533-JAZZ (5299) For Defitelio®, Rylaze™, Vyxeos®, Xyrem®, Xywav®, or Zepzelca®support, contact JazzCares via phone or visit JazzCares.com. Health care providers may request to be contacted by a Jazz Access and Reimbursement Manager (ARM) for assistance with additional reimbursement-related questions.

  3. Please call your healthcare provider if you have questions about XYREM, or you can contact the REMS toll free at 1-866-997-3688. You can reach a pharmacist at this number 24 hours a day, 7 days a week with any questions. We hope you find this information and the REMS services helpful. Sincerely, Jazz Pharmaceuticals.

  4. Get answers. For further information, visit or call. XYWAVXYREMREMS.com. 1-866-997-3688. A JazzCares ® Nurse Case Manager is available. Monday – Friday, 7 AM – 8 PM, Central Time. A pharmacist is available 24 hours a day, 7 days a week. Important Safety Information. WARNING: CENTRAL NERVOUS SYSTEM DEPRESSION and ABUSE AND MISUSE.

  5. Refilling your XYREM is easy and convenient with our online refill scheduling and reminder. Sign up to receive email and text reminders today. Call the pharmacy at 1-866-997-3688 to sign up!

  6. Success Program by calling the following toll-free phone number: 1-866- 5XYREM5 (1-866-599-7365). Treatment should be initiated by and remain under the guidance of a physician.

  7. The online REMS Patient Enrollment Form can be found here. Submit the completed and signed front page of the XYWAV Prescription Form to the Certified Pharmacy by either: Online. XYWAVXYREMREMS.com. Fax. 1-866-470-1744 (toll-free) Mail. XYWAV and XYREM REMS PO Box 66589 St. Louis, MO 63166-6589. Keep the following additional information in mind.

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