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1 IU of tocopherol is defined as ⅔ milligrams of RRR -α-tocopherol (formerly named d-α-tocopherol or sometimes ddd-α-tocopherol). 1 IU is also defined as 1 milligram of an equal mix of the eight stereoisomers, which is a racemic mixture called all-rac -α-tocopheryl acetate.
One IU of tocopherol is defined as 2 ⁄ 3 milligram of RRR-α-tocopherol (formerly named d-α-tocopherol). 1 IU is also defined as 0.9 mg of an equal mix of the eight stereoisomers, which is a racemic mixture, all-rac-α-tocopheryl acetate.
1 mg of alpha-tocopherol is equivalent to 1.49 IU of the natural form or 2.22 IU of the synthetic form. To convert from IU to mg: 1 IU of the natural form is equivalent to 0.67 mg of alpha-tocopherol.
5 Ιαν 2021 · 1 IU of the natural form is equivalent to 0.67 mg of alpha-tocopherol. 1 IU of the synthetic form is equivalent to 0.45 mg of alpha-tocopherol.
The international unit measurement was used by the United States in 1968–2016. 1 IU is the biological equivalent of about 0.667 mg d (RRR)-alpha-tocopherol (2/3 mg exactly), or of 0.90 mg of dl-alpha-tocopherol, corresponding to the then-measured relative potency of stereoisomers.
Before 1980, for pharmacological uses, one international unit (IU) of vitamin E activity was defined as 1 mg of all rac-α-tocopheryl acetate by the United States Pharmacopeia (USP) (USP, 1979). Using the rat fetal resorption assay, 1 mg of RRR-α-tocopherol was calculated to be equivalent to 1.49 IU of vitamin E (Weiser and Vecchi, 1981).
Alpha-tocopherol (59-02-9) is the primary form of vitamin E that is preferentially used by the human body, and it has the highest bioavailability out of all of the alpha-tocopherol stereoisomers. This vitamin is well known for its antioxidant, cytoprotective, free radical scavenging abilities.
