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Zidovudine (ZDV), also known as azidothymidine (AZT), was the first antiretroviral medication used to prevent and treat HIV/AIDS. It is generally recommended for use in combination with other antiretrovirals. [ 6 ]
In the laboratory, AZT suppressed HIV replication without damaging normal cells, and the British pharmaceutical company Burroughs Wellcome funded a clinical trial to evaluate the drug in people with AIDS.
19 Μαρ 2017 · These so-called antiretroviral drugs have made it possible for people diagnosed with HIV to live long and relatively healthy lives, as long they continue to take the medications.
AZT, drug used to delay development of AIDS (acquired immunodeficiency syndrome) in patients infected with HIV (human immunodeficiency virus). AZT belongs to a group of drugs known as nucleoside reverse transcriptase inhibitors (NRTIs). In 1987 AZT became the first of these drugs to be approved by.
Physicians now have approximately thirty antiretroviral products, formulated either singly or in combination, to treat patients with human immunodeficiency virus (HIV-1), the pathogenic retrovirus which causes the acquired immunodeficiency syndrome (AIDS) and related conditions (Table 1).
5 Ιουν 2023 · Zidovudine functions as an anti-viral agent by being incorporated into newly made viral DNA in place of thymidine and acting as a viral DNA chain terminator. This inhibits the ability of HIV-1 reverse transcriptase to make viral DNA from the RNA template, which interferes with the HIV-1 life cycle.
The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS.
