Αποτελέσματα Αναζήτησης
CD8 + T cells are recognized as T C cells once they become activated and are generally classified as having a pre-defined cytotoxic role within the immune system. However, CD8 + T cells also have the ability to make some cytokines, such as TNF-α and IFN-γ, with antitumour and antimicrobial effects.
15 Σεπ 2020 · Cytotoxic CD8 + T cells are major killers of pathogens and neoplastic cells, with CD4 + T cells playing important roles in the maintenance of the CD8 + response and prevention of...
1 Νοε 2023 · As typical cytotoxic CD8 + T cells, Tc1 cells produce perforin, granzyme B, IFN-γ, and TNF-α, which enable them to eliminate tumor and infected cells. The activation of Tc1 cells is promoted by...
1 Ιαν 2021 · This review summarises advances in research into cytotoxic CD8 + T cells, the most prominent effector cell type in cancer and cancer immunotherapy.
Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of current successful cancer immunotherapies.
12 Μαΐ 2021 · Cytolytic effector CD8 + T cells help to eliminate pathogens through cytokine secretion and direct killing of infected cells, while long-lived memory CD8 + T cell populations provide...
Abstract. CD8 + T cells are end effectors of cancer immunity. Most forms of effective cancer immunotherapy involve CD8 + T cell cytotoxic function. Here we review the current understanding of T cell function in cancer, focusing on key CD8 + T cell subtypes and states. We discuss factors that influence CD8 + T cell differentiation and function in cancer through a framework that incorporates the ...
