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As the field has matured, recent efforts have focused more on human studies, so the endocrinology of inhibin, activin, and FS in the human is summarized first. Another area receiving significant recent attention is local actions of activin and its regulation by both FS and inhibin.
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As the field has matured, recent efforts have focused more...
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Inhibins and activins are considered members of the transforming growth factor-beta (TGF-8) superfamily of growth and differentiation factors, based on a pattern of conserved cysteine residues in the a and g subunits, similar to other ligands in the family.
15 Αυγ 2012 · Four β-subunit human genes have been characterised, βA, βB, βC, and βE, but only the βA/βA (activin A), βB/βB (activin B), and βA/βB (activin AB) dimers have been studied in detail. Heterodimerisation of the activin β-subunits with the inhibin α-subunit results in inhibin A (α/βA) and inhibin B (α/βB).
Betaglycan is a coreceptor that enhances inhibin’s antagonism of activin signaling (Figs. 1C, 2F). The inhibin β subunit binds to one type II activin receptor, competing directly with activin binding. However, the inhibin α subunit cannot bind a second type II receptor.
1 Ιουλ 2016 · Since their original discovery as regulators of follicle-stimulating hormone (FSH) secretion and erythropoiesis, the TGF-β family members activin and inhibin have been shown to participate in a variety of biological processes, from the earliest stages of embryonic development to highly specialized f ….
1 Απρ 2001 · Cells treated with inhibin A or inhibin B alone resulted in a partial antagonism of activin-stimulated p3TP-luc, while inhibin B treatment in the presence of cotransfected InhBP virtually abolished activin-stimulated p3TP-luc expression.
Analysis of the inhibin and activin subunit genes is now providing insight into the signaling pathways and molecular mechanisms by which inhibin and activin subunit gene expression is modulated in the ovary and testis.
