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As the field has matured, recent efforts have focused more on human studies, so the endocrinology of inhibin, activin, and FS in the human is summarized first. Another area receiving significant recent attention is local actions of activin and its regulation by both FS and inhibin.
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1 Νοε 2002 · As the field has matured, recent efforts have focused more on human studies, so the endocrinology of inhibin, activin, and FS in the human is summarized first. Another area receiving...
1 Οκτ 2002 · TLDR. Recent findings suggest that it may be more appropriate to consider a new paradigm for inhibin, activin, and FS in which activin signaling is regulated extracellularly by both inhibin and FS whereas a number of intracellular proteins act to modulate cellular responses to these activin signals. Expand.
FSH levels stimulate inhibin B secretion, which then feeds back to the pituitary to downregulate FSH secretion. In humans, FSH administration during the early follicular phase results in a robust and dose-dependent response by both inhibin B and inhibin A, although inhibin B is more responsive to a lower dose of
1 Οκτ 2002 · Europe PMC is an archive of life sciences journal literature.
Inhibins and activins were initially recognized as gonadal protein hormones which modulate follicle-stimulating hormone (FSH) production by the anterior pituitary gland.
Inhibin and follistatin are two potent antagonists of activin, regulating its inductive effects via two distinct inhibitory loops. Inhibin is a heterodimer that consists of one subunit identical to activin and another unique alpha-subunit ( Nakamura et al . 1998 ).
