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A base pair (bp) is a fundamental unit of double-stranded nucleic acids consisting of two nucleobases bound to each other by hydrogen bonds. They form the building blocks of the DNA double helix and contribute to the folded structure of both DNA and RNA.
Qualitatively, guanine (G) and cytosine (C) undergo a specific hydrogen bonding with each other, whereas adenine (A) bonds specifically with thymine (T) in DNA and with uracil (U) in RNA. Quantitatively, each GC base pair is held together by three hydrogen bonds, while AT and AU base pairs are held together by two hydrogen bonds.
25 Ιουλ 2022 · In double stranded DNA, the guanine (G) base on one strand can form three H-bonds with a cytosine (C) base on another strand (this is called a GC base pair). The thymine (T) base on one strand can form two H-bonds with an adenine (A) base on the other strand (this is called an AT base pair).
15 Μαΐ 2022 · The rules of base pairing explain the phenomenon that whatever the amount of adenine (A) in the DNA of an organism, the amount of thymine (T) is the same (called Chargaff's rule). Similarly, whatever the amount of guanine (G), the amount of cytosine (C) is the same.
29 Οκτ 2009 · The figure shows that the base pair that has the shortest contact distance with the arginine guanidinium group has a 78% probability of being an AT and 22% of being a GC.
In canonical Watson–Crick base pairing in DNA, adenine (A) forms a base pair with thymine (T) using two hydrogen bonds, and guanine (G) forms a base pair with cytosine (C) using three hydrogen bonds. In canonical Watson–Crick base pairing in RNA, thymine is replaced by uracil (U).
30 Οκτ 2019 · In this study, we consider the canonical RNA base-pairs to be the two Watson–Crick base-pairs, GC and AU, and the weaker GU wobble base-pair (GC, AT, and GT base-pairs in DNA, respectively).
