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24 Μαΐ 2023 · Immunofixation consists of an electrophoresis phase and a fixation phase. In the former, the serum is applied to an agarose gel, and the negatively charged serum proteins move toward the...
- Multiple Myeloma
Multiple myeloma (MM) is a plasma cell malignancy in which...
- Multiple Myeloma
An immunofixation blood test, also known as protein electrophoresis, measures certain proteins in the blood. Proteins play many important roles, including providing energy for the body, rebuilding muscles, and supporting the immune system.
An immunofixation (IFE) blood test measures the number and type of proteins in your blood. Proteins have many important functions, including giving your body energy, rebuilding muscles, and helping your immune system.
Immunofixation permits the detection and typing of monoclonal antibodies or immunoglobulins in serum or urine. It is of great importance for the diagnosis and monitoring of certain blood related diseases such as myeloma.
Immunofixation, since it is the most sensitive method for detecting M proteins, is the preferred method in the laboratory evaluation of neuropathies. Other methods, such as serum protein electrophoresis, may not detect some M proteins.
Immunofixation electrophoresis (IFE) is a technique for the identification of proteins within complex mixtures after separation by either conventional zone electrophoresis or isoelectric focusing.
Immunofixation is the preferred technique for identifying a monoclonal light chain in urine. A 24-hour urine specimen should be collected and the amount of M protein calculated on the basis of the densitometer tracing and the 24-hour urine protein content.
