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The key to developing a guideline-based protocol unique to each laboratory is that nebulizer manufacturers must properly characterize the aerosol output of their devices so that the laboratory can select the correct methacholine concentrations and dilution schedules.
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The hand bulb nebulizer (Yan protocol) is infrequently used...
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Methacholine challenge testing. Methacholine is a synthetic derivative of the neurotransmitter acetylcholine and directly stimulates muscarinic (M3) receptors on airway smooth muscle when inhaled.
22 Μαΐ 2023 · Methacholine challenge testing is the most common form of bronchoprovocation testing, utilizing the longer-acting acetylcholine derivative methacholine to induce bronchoconstriction. Direct bronchial challenge testing, chemically triggering airway smooth muscle receptors.
The hand bulb nebulizer (Yan protocol) is infrequently used in the United States and has poorer reproducibility when used with patients who have not previously performed methacholine challenge tests . It is widely used for epidemiological surveys.
The key to developing a guideline-based protocol unique to each laboratory is that nebulizer manufacturers must properly characterize the aerosol output of their devices so that the laboratory can select the correct methacholine concentrations and dilution schedules.
Results: Using independently referenced (within the ERS standard) validation data from a breath actuated nebulizer (AeroEclipse* BAN) and 1 minute tidal breathing, it was possible to expand upon the five identified steps in order to provide example methacholine concentrations, dilutions and associated delivered doses.
TITLE: Nebulizers for the Methacholine Challenge Test: Diagnostic Accuracy and Guidelines. DATE: . 9 May 2014. RESEARCH QUESTIONS. What is the diagnostic accuracy of the English-Wright nebulizer compared with the AeroEclipse II nebulizer for the methacholine challenge test in the diagnosis of asthma?
