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Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor, in that it was one of the first to be described.
Nerve growth factor (NGF) is a neurotrophin involved in several processes, including survival, apoptosis, differentiation, and maturation of neurons (Freed, 1976). NGF is also known as an inflammatory mediator particularly associated with chronic airway diseases (Allen and Dawbarn, 2006).
Since its discovery, nerve growth factor (NGF) has long occupied a critical role in developmental and adult neuro-biology for its many important regulatory functions on the survival, growth and differentiation of nerve cells in the peripheral and central nervous system.
29 Νοε 2012 · The physiological role of the neurotrophin nerve growth factor (NGF) has been characterized, since its discovery in the 1950s, first in the sensory and autonomic nervous system, then in central nervous, endocrine and immune systems.
21 Ιουλ 2016 · Recent progress in the Nerve Growth Factor (NGF) research has shown that this factor acts not only outside its classical domain of the peripheral and central nervous system, but also on non-neuronal and cancer cells.
The physiological role of NGF as a neurotrophic factor in the peripheral nervous system is well established. NGF is essential for the development and maintenance of specific functions of peripheral sympathetic and neural-crest derived sensory neurons. NGF acts as a...
Nerve growth factor (NGF), the best characterized member of the neurotrophin family, sends its survival signals through activation of TrkA and can induce cell death by binding to p75 NTR.
