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20 Μαΐ 2020 · The FDA has approved three medications for alcohol use disorder: naltrexone, acamprosate, and disulfiram. Additionally, other medications including gabapentin, baclofen, topiramate, and ondansetron show promise off-label for treating alcohol use disorder.
3 Σεπ 2024 · Pharmacologic treatment of alcohol use disorder has focused on altering the reinforcing effects of alcohol use. Medication development has focused on several neurotransmitter systems that mediate reinforcement including opioid, glutamate, gamma-aminobutyric acid, and serotonin systems.
Pharmacologic treatment: Currently, 3 medications are approved by the U.S. Food and Drug Administration for the treatment of AUD: acamprosate, naltrexone, and disulfiram. Gabapentin and topiramate are additional evidence-based options for treatment.
While benzodiazepines represent the gold standard treatment of alcohol withdrawal syndrome, there is no evidence that benzodiazepines may be effective for treating AUD. The lack of efficacy combined with the significant risk of abuse does not support any efforts to use or test this class of medications for AUD. There is also a significant risk ...
This chapter summarizes work on clinically available medications (both approved by regulatory bodies and investigational) for the treatment of alcohol dependence, as well as the psychiatric disorders that are commonly comorbid with AUD.
In this systematic review and meta-analysis that included 118 clinical trials, the highest strength of evidence for treatment of alcohol use disorder was available for acamprosate and oral naltrexone (50 mg/d).
A combination of psychosocial intervention and pharmacotherapy is the cornerstone of AUD treatment. Despite their efficacy, safety and cost-effectiveness, clinicians are reluctant to prescribe medications to treat individuals with AUD.
