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Sickle-cell anaemia (also known as sickle-cell disorder or sickle-cell disease) is a common genetic condition due to a haemoglobin disorder – inheritance of mutant haemoglobin genes from both parents. Such haemoglobinopathies, mainly thalassaemias and sickle-cell anaemia, are globally widespread.
• Evidence-based treatment guidelines for sickle cell disease complications that affect the heart, lungs, and kidneys. • SCD affects multiple organs that require patients to seek care from doctors that
30 Μαΐ 2022 · Sickle cell disease and its variants constitute the most common inherited blood disorders affecting millions of individuals worldwide. Significant information regarding the nature of the...
7 Μαΐ 2019 · Sickle cell disease (SCD) is a monogenetic disorder due to a single base-pair point mutation in the β-globin gene resulting in the substitution of the amino acid valine for glutamic acid in...
16 Απρ 2020 · PDF. Abstract. Background: Central nervous system (CNS) complications are among the most common, devastating sequelae of sickle cell disease (SCD) occurring throughout the lifespan. Objective:
24 Ιαν 2019 · Based on current evidence, the pathobiology of SCD is considered to be a vicious cycle of four major processes, all the subject of active study and novel therapeutic targeting: (a) hemoglobin S...
15 Ιουλ 2017 · Sickle cell disease is caused by the inheritance of abnormal beta-globin alleles carrying the sickle mutation on the HBB gene (Glu6Val, βS). The most common and severe form is homozygous HbSS (sickle cell anaemia) with inheritance of βS from both parents, which permits formation of the pathological sickle haemoglobin tetramer (α2βS 2, HbS).
