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31 Αυγ 2021 · Sodium bicarbonate for lactic acidosis has been compared with saline in two small-scale randomized, crossover, single center trials [20, 21]. Cooper et al. reported that sodium bicarbonate administration increased pH and PCO2 with no change in blood pressure or cardiac output .
Patients had similar pH, arterial carbon dioxide, and bicarbonate at ICU admission, while after 48 h, nonsurvivors had lower pH, higher carbon dioxide, and similar bicarbonate, despite similar infusions of sodium bicarbonate. 35
7 Ιουλ 2018 · Therefore, we aimed to evaluate whether sodium bicarbonate infusion would improve these outcomes in critically ill patients. Methods: We did a multicentre, open-label, randomised controlled, phase 3 trial. Local investigators screened eligible patients from 26 intensive care units (ICUs) in France.
16 Φεβ 2023 · Summary. Metabolic acidosis is a common clinical feature among individuals admitted to the intensive care unit. Severe acidosis has been correlated with worsened outcomes. Sodium bicarbonate use for correction of metabolic acidosis has become common practice in the critically ill patient.
1 Αυγ 2023 · The trial used a 4.2% sodium bicarbonate infusion to target a pH > 7.3 in critically ill patients admitted to the ICU—and did not include patients in the emergency department or those who had received a bicarbonate infusion in the 24 h prior to enrollment.
4.2% sodium bicarbonate intravenously infused aim of achieving an arterial pH of 7⋅30 or more during the 28 day ICU admission or ICU discharge; protocol recommended that the volume of each sodium bicarbonate infusion should be within the range of 125–250 mL in 30 min, with a maximum of 1000 mL within 24 h after inclusion
1 Ιουν 2019 · Sodium bicarbonate therapy is common in the ICU; however, our synthesis of the available literature suggests the evidence underlying its efficacy and/or safety is very weak. In paediatric patients with diabetic ketoacidosis, treatment with NaHCO3 is believed to increase the risk of cerebral oedema [ 52 ].
