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12 Ιαν 2020 · In the presence of ultraviolet light, two adjacent thymine molecules often mutate to form a thymine dimer. A dimer kinks the DNA molecule, affecting its function, plus the dimer cannot be correctly transcribed (replicated) or translated (used as a template to make amino acids).
One of the common mutations of DNA involves two adjacent thymines or cytosine, which, in presence of ultraviolet light, may form thymine dimers, causing "kinks" in the DNA molecule that inhibit normal function. Thymine could also be a target for actions of 5-fluorouracil (5-FU) in cancer treatment. 5-FU can be a metabolic analog of thymine (in ...
28 Απρ 2017 · When exposed to ultraviolet radiation such as sunlight, covalent bonds are formed between adjacent thymine molecules on the same strand of DNA, creating thymine dimers. This process causes damage, by causing the DNA to form ‘kinks’. This inhibits the normal function of the DNA, which cannot then be replicated or transcribed. Thymine Dimers
Thymine is a fundamental building block of DNA, playing a critical role in the structure, stability, and genetic information storage of living organisms. Its complementary base pairing with adenine and its presence in the genetic code highlight its significance in molecular biology.
21 Φεβ 2022 · In this paper, we focus on the interaction between supercoiling and inhomogeneities caused by thymine dimers, the most common of several types of mutagenic lesions caused by UV irradiation of DNA. They are perhaps the best known and studied DNA damage system (19).
Direct repair of thymine dimers. UV-induced thymine dimers can be repaired by photoreactivation, in which energy from visible light is used to split the bonds forming the cyclobutane ring. Another form of direct repair deals with damage resulting from the reaction between alkylating agents and DNA.
2 Φεβ 2007 · In order for this methodology to achieve its full potential, molecular-level understanding of the dimerization mechanism is essential. We report a dynamic study of thymine dimerization that provides insight into the coupling between DNA structure and DNA photodamage.
