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By 1918, the successful use of some vaccines, especially those against rabies, typhoid fever, and diphtheria, as well as the use of diphtheria anti-toxin, had raised high expectations for a vaccine against influenza. 12 Those who already had a vaccine in hand were quick off the mark to promote their vaccines as sure preventives or cures for ...
31 Αυγ 2018 · Understanding how such a virulent epidemic emerged and spread offers hope for prevention and strategies of response. This review uses historical methodology and evolutionary perspectives to revisit the 1918 outbreak.
Following it are three essays that frame the 1918 influenza pandemic in terms of the biological history of the virus, the response of scientists who unsuccessfully sought to produce an effective vaccine, and the guiding parameters of urban public health during the early 20th century.
8 Απρ 2024 · The 1918 pandemic influenza virus HA with a Q189R mutation has not yet been evaluated using a glycan array. It might be suspected that these mutational differences in the HA receptor binding domain would lead to differences in viral binding, infectivity, and pathogenic potential.
Data from U.S. military training camps in 1918 indicated that the odds of influenza cases being complicated by bronchopneumonia in September–October 1918 were approximately 25-fold higher than they had been in the December 1917–April 1918 pre-pandemic peaks of influenza-like illnesses .
1 Απρ 2007 · In this review we address several of these questions, concerning pandemic-virus origin, unusual epidemiologic features, and the causes and demographic patterns of fatality.
4 Απρ 2019 · Challenges to producing a truly universal influenza vaccine include eliciting broad protection against antigenically different influenza viruses that can prevent or significantly downregulate viral replication and reduce morbidity by preventing development of viral and secondary bacterial pneumonia.
