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Proteasome inhibition acts through multiple mechanisms to induce cell death. Inhibition of NF-κB results in downregulation of multiple pro-neoplastic pathways. Activation of the JNK pathway leads to caspase activation and apoptosis.
- Exploring the Proteolysis Mechanism of the Proteasomes
The canonical form of the proteasome in eukaryotes is known...
- Exploring the Proteolysis Mechanism of the Proteasomes
1 Ιαν 2001 · The 26S proteasome is a 2.4 MDa multifunctional ATP-dependent proteolytic complex, which degrades the majority of cellular polypeptides by an unusual enzyme mechanism.
3 Οκτ 2024 · The 26S proteasome is involved in degrading and regulating the majority of proteins in eukaryotic cells, which requires a sophisticated balance of specificity and promiscuity.
13 Σεπ 2020 · The major mechanism of action of bortezomib in MM is the inhibition of the chymotrypsin-like site of the 20S proteolytic core, thereby inducing cell-cycle arrest and apoptosis though suppressing NF-κB signaling.
The canonical form of the proteasome in eukaryotes is known as 26S proteasome, which is a 2.5 MDa protein complex.
24 Ιαν 2017 · Bortezomib is a slowly reversible inhibitor, which binds the catalytic site of the 26S proteasome, enabling inhibition of the β5/chymotrypsin-like and, to a lesser extent, the β2/trypsin-like ...
20 Ιαν 2005 · Its mechanism of action is partly mediated through nuclear factor-kappa B inhibition, resulting in apoptosis, decreased angiogenic cytokine expression, and inhibition of tumor cell adhesion to stroma. Additional mechanisms include c-Jun N-terminal kinase activation and effects on growth factor expression.
