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The typical clinical presentation of small fibre neuropathy is that of a symmetrical, length-dependent polyneuropathy associated with sensory or autonomic symptoms. More rarely, the clinical presentation is characterised by non-length-dependent, focal, or multifocal symptoms.
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Terkelsen A J, Karlsson P, Lauria G, Freeman R, Finnerup N...
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Small fiber neuropathy (SFN) is a disorder of the small myelinated Aδ-fibers and unmyelinated C-fibers . SFN might affect small sensory fibers, autonomic fibers or both, resulting in sensory changes, autonomic dysfunction or combined symptoms [ 7 ].
Small fibers have receptors for and release immune or inflammatory signals distally. They contact mast cells and microvessels. Neurogenic inflammation mediated by C-fibers is sometimes visible as flushing and swelling in focal or generalized small-fiber neuropathy (Figure 2A and C).
Small fiber neuropathy has a benign course but can affect quality of life; individualize treatment to control underlying causes and alleviate pain. Small fiber neuropathy (SFN) is common and can be associated with many medical conditions, including reports of an association with COVID-19.
12 Δεκ 2022 · Small fiber neuropathy presents with burning pain, often beginning in the extremities, most notably in the feet. It is due to the involvement of A-delta and C nerve fibers. It may occur idiopathically or due to metabolic, hereditary, infectious, immune-mediated, or toxic etiologies.
1 Οκτ 2018 · Small fiber neuropathy, which affects the sensory Aδ and C fibers, is now a major diagnostic and therapeutic challenge. Nearly 7% of the general population have chronic neuropathic pain responsible for severe quality-of-life impairments.
26 Νοε 2019 · Small fiber neuropathy (SFN) occurs as a result of injury to the small unmyelinated C or thinly myelinated (Aδ) nerve fibers, which have both sensory and autonomic functions [1, 2, 3••]. Patients with SFN present with a variety of subjective symptoms and minimal abnormalities in physical examination or conventual neurological testing [ 3
