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  1. 1 Μαΐ 2018 · Dose-Dense AC + TH is often given with the goal of cure and administered either before surgery (neoadjuvant therapy) to shrink the size of the tumor, or after surgery (adjuvant therapy) to kill any cancer cells that may be still present in the body.

  2. 6 Οκτ 2011 · Background. Trastuzumab improves survival in the adjuvant treatment of HER-positive breast cancer, although combined therapy with anthracycline-based regimens has been associated with cardiac...

  3. Treatment overview. This treatment regimen consists of two parts: 4 cycles of AC, followed by 4 cycles of TH and 13 cycles of trastuzumab. Breast neoadjuvant/adjuvant AC (DOXOrubicin and CYCLOPHOSPHamide) three weekly. Breast adjuvant TH (DOCEtaxel and trastuzumab) three weekly.

  4. The rate of peripheral neuropathy is similar to the rates previously reported in the PATTERN trial and CBCSG-010 trial in our centre. Besides, WSG Plan B trial reported 0.8–2.2% of grade 3–4 peripheral neuropathy as well.

  5. Cardiovascular complications covered in this 2-part review are heart failure (HF), myocardial ischemia, myocarditis, hypertension (HTN), pulmonary HTN, pericardial diseases, thromboembolism, QT prolongation and arrhythmias, and radiation-induced cardiovascular diseases.

  6. AC chemotherapy works by stopping the cancer cells from dividing and multiplying, which blocks the growth of the cancer. Different chemotherapy drugs attack cancer cells at different stages of their growth.

  7. 31 Ιουλ 2017 · An analysis of the SEER-Medicare database shows that outcomes and healthcare costs for the two chemotherapy regimens are similar, with one difference.

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