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2 Απρ 2012 · The overarching question for this clinical practice guideline is: Should actual body weight be used to select chemotherapy doses in obese individuals with cancer? For adults, overweight and obesity ranges are determined by using weight and height to calculate BMI.
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Purpose To provide recommendations for appropriate cytotoxic...
- The Calculation of Actual Or Received Dose Intensity
Two recent reports of the same combination chemotherapy...
- Evaluation of Chemotherapy in Older Patients—An Analysis of The Medical Literature
The high incidence of age-related hearing loss should also...
- Dose Calculation of Anticancer Drugs
Loss of estrogen receptor in recurrent breast cancer is...
- Prognostic Significance of Actual Dose Intensity in Diffuse Large-Cell Lymphoma
New Journal: JCO Oncology Advances. Editorials September 12,...
- Paclitaxel Pharmacokinetics, Threshold Models, and Dosing Strategies
New Journal: JCO Oncology Advances. Editorials September 12,...
- Incidence and Predictors of Low Dose-Intensity in Adjuvant Breast Cancer Chemotherapy
Results: Dose reductions ≥15% occurred in 36.5% of patients,...
- Social and Racial Differences in Selection of Breast Cancer Adjuvant Chemotherapy Regimens
Purpose Breast cancer outcomes are worse among black women...
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3 Μαΐ 2021 · The Panel continues to recommend that full, weight-based cytotoxic chemotherapy doses be used to treat obese adults with cancer. New to this version of the guideline, the Panel also recommends that full, approved doses of immunotherapy and targeted therapies be offered to obese adults with cancer.
4 Φεβ 2021 · Comparisons between the different groups found both dietary interventions (MD -1.56kg, 95% CrI -3.12 to +0.17kg) and combination interventions (MD -1.82kg, 95% CrI -3.43 to -0.50kg) to be associated with greater weight loss than exercise interventions.
Panel recommends that full weight–based chemotherapy doses be used in the treatment of the obese patient with cancer, particularly when the goal of treatment is cure.
25 Νοε 2020 · Several leading health authorities recommend the management of excess weight (e.g., avoiding weight gain, intentional weight loss and weight-loss maintenance) for people living with...
The given average dose intensity was F 185 mg/m2/2, E 26.4 mg/m2/2 and C 336 mg.m2/2 (representing 93%, 132% and 168% of intended doses of standard regimen). Overall response rate for 21 patients was 81%; CI, 66% to 96%), including six complete responses (23%; CI 7 %-39%).
A. Yes – clinicians should calculate weight-based doses for cytotoxic chemotherapy regardless of a patient’s obesity status. While there are not enough high quality studies about morbidly obese, the Panel recommends full weight-based dosing, if other comorbidities are not a contraindication. Q.
