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26 Απρ 2016 · Less cardiotoxicity is seen with TCH (docetaxel, carboplatin, and trastuzumab) than with AC→TH (doxorubicin and cyclophosphamide→docetaxel and trastuzumab), and TCH is recommended for patients at higher risk for cardiotoxicity.*
17 Ιουν 2017 · In this trial, administration of anthracycline followed by docetaxel every 3 weeks (AC-T) was compared with the following two regimens: AC-T plus 52 weeks of trastuzumab (AC-TH), or docetaxel and carboplatin plus 52 weeks of trastuzumab starting with the first dose of chemotherapy (TCH).
AC (Adriamycin® + Cyclophosphamide) followed by THP (Taxol® + Herceptin® + Pertuzumab) is a Chemotherapy Regimen for Breast Cancer - early stage. How does AC-THP work? Doxorubicin, cyclophosphamide, and paclitaxel are chemotherapy drugs designed to kill or slow the growth of cancer cells.
In this study (N = 121), pCR was numerically higher with pertuzumab based regimens, including ddAC-THP (60%), TCHP (63%), THP (55%), as compared with ddAC-TH (46%). THP resulted in significantly less cycle delays due to toxicity compared to the other regimens (p=0.02).
14 Ιουν 2021 · The N9831 and NSABP B-31 trials evaluated the benefit and tolerability of adding trastuzumab to paclitaxel in the standard AC-T (doxorubicin and cyclophosphamide followed by paclitaxel) regimen in HER2-positive early breast cancer. 26 The study arms that included trastuzumab had fewer events compared to the chemotherapy alone groups (HR, 0.48 ...
An adaptive-treatment strategy beginning with neoadjuvant THP or TH followed by tailoring post-operative therapy reduces treatment costs, and spares toxicity compared to more intensive chemotherapy regimens for women with HER2-positive breast cancer.
5 Νοε 2021 · Here, the authors present the efficacy and biomarker analysis of two HER2-targeted combinations (ado-trastuzumab emtansine plus pertuzumab and paclitaxel, trastuzumab and pertuzumab) in the ...
