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  1. 17 Ιουλ 2013 · If not at target, stage 1: Start with lifestyle and metformin. If A1C ≥7.5% (10) or ≥9% (9, 10), consider short-term combination therapy or insulin, respectively. Stage 2: If A1C is not at target after 36 months of metformin therapy, suggest adding incretin therapy (in relation to BMI).

  2. 8 Οκτ 2014 · Based on these studies, TCH, AC-TH, and sequential anthracycline–trastuzumab are standard adjuvant therapy options in this population. Adjuvant chemotherapy is recommended even for small node-negative HER2-breast cancer, but the threshold for treatment is disputed.

  3. 1 Μαΐ 2018 · Dose-Dense AC + TH is often given with the goal of cure and administered either before surgery (neoadjuvant therapy) to shrink the size of the tumor, or after surgery (adjuvant therapy) to kill any cancer cells that may be still present in the body.

  4. 14 Δεκ 2023 · This topic review will cover the use of adjuvant HER2-directed therapy plus chemotherapy in patients with HER2-positive, early-stage breast cancer (stage I to III).

  5. 26 Απρ 2016 · Docetaxel plus cyclophosphamide (TC) × 4 is recommended as an alternative to AC × 4 and offers improved disease-free survival (DFS) and overall survival (OS). Classic CMF with oral cyclophosphamide for six cycles is another option.

  6. 15 Φεβ 2019 · The first-line treatment option, metformin, is safe and fairly well-tolerated, has excellent long-term efficacy for patient-oriented outcomes, is moderately priced, and has a simple dosing...

  7. 21 Απρ 2021 · Adherence therapy has been shown to be an effective adjunct treatment in long-term conditions including hypertension. The purpose of this study is to review and critically appraise evidence on the effectiveness of adherence therapy as an intervention in adults with type 2 diabetes.