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EXCLUSIONS: Pregnancy. Significant cardiovascular disease and/or LVEF less than 50%; if initial reading is less than 50%, physician may consider repeating for validity, or assessing LVEF by the other modality, e.g. echocardiogram instead of MUGA. Known hypersensitivity to E. coli derived products.
26 Απρ 2016 · PDF. Adjuvant chemotherapy improves disease-free survival (DFS) and overall survival (OS) independent of age, nodal status, and estrogen receptor (ER) status.
3 Δεκ 2020 · Patients diagnosed with breast cancer during pregnancy can be safely treated with chemotherapy starting from the second trimester. The choice of the regimen should follow the guidelines for non-pregnant patients, anthracyclines and taxanes being the standard of care after the first trimester.
This treatment regimen consists of two parts: 4 cycles of AC, followed by 4 cycles of TH and 13 cycles of trastuzumab. Breast neoadjuvant/adjuvant AC (DOXOrubicin and CYCLOPHOSPHamide) three weekly. Breast adjuvant TH (DOCEtaxel and trastuzumab) three weekly.
Here, we provide the ESMO Clinical Practice Guidelines for managing patients diagnosed with cancer during pregnancy. Also, we provide guidance on fertility considerations for women desiring pregnancy following cancer diagnosis.
1 Μαΐ 2018 · Dose-Dense AC (DD-AC, Doxorubicin + Cyclophosphamide) + TH (Taxol® + Herceptin®) is a Chemotherapy Regimen for Breast Cancer - early stage. How does Dose-Dense AC + TH work? Doxorubicin, cyclophosphamide, and paclitaxel are designed to kill or slow the growth of cancer cells.
G-CSF support (using standard or pegylated form) is required with all cycles of dose dense DOXOrubicin and cycloPHOSphamide. Facilities to treat anaphylaxis MUST be present when the systemic anti-cancer therapy (SACT) is administered.
