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20 Απρ 2021 · Reverse transcription loop-mediated isothermal amplification (RT-LAMP) has been validated to diagnose several viral infections. However, its diagnostic accuracy in detecting SARS-CoV-2 in real-life clinical settings remains unclear.
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Figure 2 - Diagnostic accuracy of LAMP versus PCR over the...
- Table 1
Table 1 - Diagnostic accuracy of LAMP versus PCR over the...
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Open in a Separate Window - Diagnostic accuracy of LAMP...
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Accuracy of RT LAMP compared with SoD or Liferiver was 83% (confidence interval 95%, CI, 79−87%) and 86% (95% CI, 82−90%), respectively. Concordance, determined by the Cohen's Kappa value, was 0.57 (95% CI, 0.48–0.67) for SoD and 0.66 (95% CI, 0.57–0.74) for Liferiver.
In the present study, we have aimed to evaluate the diagnostic accuracy of RT-LAMP compared with RT-qPCR in actual clinical settings. Therefore, we have not examined the quantity and quality of RNA and have performed these assays in singlicate per sample as in actual clinical practice.
Amongst numerous nucleic acid amplification assays, LAMP stands out in terms of sample-to-answer time, sensitivity, specificity, cost, robustness, and accessibility, making it ideal for field-deployable diagnostics in resource-limited regions.
This study aimed to determine the diagnostic sensitivity and specificity of RT-LAMP compared to reverse transcription-quantitative polymerase chain reaction (RT-qPCR) over the disease course of COVID-19. Methods: A total of 124 nasopharyngeal swab samples obtained from 24 COVID-19 patients were tested by RT-LAMP and RT-qPCR. Sensitivities and ...
To list the available materials and methods for each type of calibration or correction for fluorescence instruments (spectral emission correction, wavelength accuracy, etc.) with a general description, the level of quality, precision and accuracy attainable, caveats, and useful references given for each entry.
1 Μαΐ 2014 · Introduction. Tuberculosis (TB) remains a major global health problem. In 2012, an estimated 8.6 million people developed TB and 1.3 million died from the disease [1]. Accurate and rapid diagnosis of TB is vitally important in establishing appropriate clinical management and infection control measures [2], [3].
