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This page looks at the reactions of acid anhydrides with water, alcohols and phenols (including the manufacture of aspirin). These reactions are all considered together because their chemistry is so similar.
23 Ιαν 2023 · This page looks at the reactions of acid anhydrides with water, alcohols and phenols (including the manufacture of aspirin). These reactions are all considered together because their chemistry is so similar.
Although slower reacting than acid chlorides, anhydrides react with water to form carboxylic acids, with alcohols to form esters, and with amines to form amides. Anhydrides can also be reduced to 1 o alcohols by hydride reduction.
Mechanism. 1) Nucleophilic Attack by the water molcule. 2) Deprotonation by pyridine. 3) Leaving group removal. 4) Protonation of the carboxylate. Acid Anhydrides react with alcohols to form esters. Reactions of anhydrides use Pyridine as a solvent. Example 1: Mechanism. 1) Nucleophilic Attack by the Alcohol. 2) Deprotonation by pyridine.
Acid anhydrides are made from two carboxylic acid groups joined together. To form an acid anhydride, a water molecule is lost in a condensation reaction between two carboxylic acids. This is why acid anhydrides are called anhydride – lack of water.
Reactions of Acid Anhydrides The chemistry of acid anhydrides is similar to that of acid chlorides, although anhydrides react more slowly. Thus, acid anhydrides react with water to form acids, with alcohols to form esters, with amines to form amides, and with LiAlH 4 to form primary alcohols.
Reactions of Acid Anhydrides With Water, Alcohols or Phenol | ChemKey. This page looks at the reactions of acid anhydrides with water, alcohols and phenols (including the manufacture of aspirin). These reactions are all considered together because their chemistry is so similar.
