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This review details how ADNI studies improved disease progression understanding and clinical trial efficiency. Advances in subject selection, detection of treatment effects, harmonization, and modeling improved clinical trials and plasma biomarkers like phosphorylated tau showed promise for clinical use.
This review details how ADNI studies improved disease progression understanding and clinical trial efficiency. Advances in subject selection, detection of treatment effects, harmonization, and modeling improved clinical trials and plasma biomarkers like phosphorylated tau showed promise for clinical use.
12 Σεπ 2023 · There has been recent interest in repurposing drugs for treatment of AD risk factors such as hypertension, inflammation, and type II diabetes mellitus (T2DM) as therapies for AD. Several ADNI studies have investigated the effects of these drugs on AD disease progression.
11 Σεπ 2024 · First, the central lab at the Mayo Clinic (the Aging and Dementia Imaging Research [ADIR] lab) is responsible for site qualification, protocol distribution, data acquisition and image quality control (QC), and identification of medical findings on participant MRI exams.
11 Σεπ 2024 · The ADNI 4 protocol contains nine different imaging types (e.g., three dimensional [3D] T1-weighted and fluid-attenuated inversion recovery [FLAIR]). Our view is that the ADNI MRI data are a greatly underutilized resource.
8 Αυγ 2024 · A summary of MRI protocols for phase four of the Alzheimer's Disease Neuroimaging Initiative (ADNI 4). The design and justification for the ADNI 4 MRI protocols. Compressed sensing and multi-band advances have been applied to improve scan time. ADNI4 protocols aim to streamline safety screening and therapy monitoring.
26 Φεβ 2008 · The ADNI MRI quality control center at the Mayo Clinic will select the better MP-RAGE sequence at each time point based on centralized and standardized criteria. Perhaps most importantly, requiring back-to-back MP-RAGE scans should reduce the number of examinations that must be repeated due to poor image quality.
