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6 Φεβ 2019 · Cancer cells possess a common metabolic phenotype, rewiring their metabolic pathways from mitochondrial oxidative phosphorylation to aerobic glycolysis and anabolic circuits, to support the energetic and biosynthetic requirements of continuous proliferation and migration.
- Molecular intricacies of aerobic glycolysis in cancer: current insights ...
Intracellularly, aerobic glycolysis circumvents...
- The Warburg Effect: How Does it Benefit Cancer Cells? - PMC
Supporting this proposal is direct evidence indicating that...
- Targeting Glucose Metabolism Enzymes in Cancer Treatment: Current and ...
Targeting Glucose Metabolism Enzymes in Cancer Treatment:...
- Molecular intricacies of aerobic glycolysis in cancer: current insights ...
1 Ιουλ 2017 · In this review, we summarized the major concepts of glucose metabolization and explore the molecular basis of aerobic glycolysis of cancer cells.
Intracellularly, aerobic glycolysis circumvents mitochondrial oxidative phosphorylation (OxPhos), facilitating an increased rate of glucose hydrolysis. This in turn enables cancer cells to successfully compete with normal cells for glucose uptake in order to maintain uninterrupted growth.
Supporting this proposal is direct evidence indicating that targeting aerobic glycolysis in the tumor has the added benefit of increasing the supply of glucose to TILs and thus boosting their main function, which is to eradicate the tumor cells.
5 Σεπ 2023 · Metabolic adaptation toward aerobic glycolysis is a common feature of cancer cells. 13 It has been documented that the glycolysis pathway contributes to immune evasion through several mechanisms. First, the tumor and immune cells compete for nutrients in the TME.
Targeting Glucose Metabolism Enzymes in Cancer Treatment: Current and Emerging Strategies. Yi Zhang. 1 Department of Radiation Oncology, Division of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
3 Δεκ 2013 · Glucose metabolism in cancer cells is primarily characterized by two major biochemical events: (i) increased glucose uptake and (ii) aerobic glycolysis, the process of conversion of glucose into pyruvate eventually resulting in the production of lactate (fermentation).
