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11 Ιουλ 2024 · Hypoventilation syndrome comprises disorders associated with alveolar hypoventilation (an elevation in PaCO₂ to levels >45 mmHg). Hypoxemia is also present in most cases, especially during sleep (PaO₂ <60 mmHg).
1 Δεκ 2008 · Central alveolar hypoventilation disorders are rare and complex disorders that may involve alterations in mechanisms of ventilatory control and autonomic dysfunction. These disorders may be congenital or acquired and are associated with significant morbidity and mortality.
Sleep-related hypoventilation is a breathing-related disorder that interrupts normal sleep. This condition may be diagnosed when all other sleep disorders have been ruled out, though it...
The ventilatory control system normally compensates for this by increasing drive to maintain adequate alveolar ventilation levels, thereby keeping arterial CO2 within its normal range. To reduce work of breathing, a pattern of reduced tidal volume and increased respiratory rate occurs.
Alveolar hypoventilation is defined as insufficient ventilation, resulting in both an increase in Paco2 and a decrease in Pao2. This is the major mechanism of nocturnal impairment in gas exchange.
Chronic alveolar hypoventilation, defined as a sustained increase in PCO2 exceeding 45 mm Hg, is a condition commonly encountered by the chest physician.
In many disease states, alveolar hypoventilation initially manifests during sleep before development of chronic hypercapnia during wakefulness. Alveolar hypoventilation, defined by increased PaCO2, occurs due to reduced minute ventilation and/or increased dead space.
