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26 Απρ 2024 · Local anesthetics (LAs) are used to block transmission of impulses in nerve fibers, to reduce or eliminate sensation. LAs may be used for neuraxial analgesia and anesthesia, peripheral nerve blocks, subcutaneous and tissue infiltration, and topical anesthesia.
17 Ιουλ 2019 · Local anaesthetic agents suppress action potentials in excitable tissues by blocking voltage-gated Na + channels. In doing so, they inhibit action potentials in nociceptive fibres and so block the transmission of pain impulses.
Chemistry—Local anesthetics are weak bases with 3 structural parts: a hydrophilic end and a lipophilic end linked by an amino ester or an amino amide bond. The bond is the basis for classifying local anesthetics into 2 groups: the amino esters and the amino amides.
Many local anesthetics fall into two general chemical classes, amino esters (top) and amino amides (bottom). A local anesthetic (LA) is a medication that causes absence of all sensation (including pain) in a specific body part without loss of consciousness, [1] providing local anesthesia, as opposed to a general anesthetic, which eliminates all ...
11 Σεπ 2023 · Local anesthetics (LAs) are drugs that block the sensation of pain in the region where they are administered. LAs act by reversibly blocking the sodium channels of nerve fibers, thereby inhibiting ...
An amide-type local anesthetic used for local or regional anesthesia during surgery and for short-term management of acute pain. Bupivacaine A local anesthetic used in a wide variety of superficial and invasive procedures.
7 Νοε 2005 · Local anaesthetics generally have a lipid-soluble hydrophobic aromatic group and a charged, hydrophilic amide group. The bond between these two groups determines the class of the drug, and may be amide or ester.
