Αποτελέσματα Αναζήτησης
In this review, we have outlined the regulatory mode of glycolysis in cancer cells and presented the regulatory mechanism of GLUT, HK, PFK, PK, LDH, and other transporters or metabolic enzymes as targets in cancers and developed target drugs.
- PubMed
The objective of this review is to present the most recent...
- PubMed
7 Σεπ 2021 · Increased glycolysis correlates with aggressive tumor progression, treatment resistance, and unfavorable prognosis in various cancers, including HNSCC 14,15,16,17.
Gaining insights into the characteristics of glycolytic enzyme expression in tumor cells can promote accurate diagnosis and prognosis assessment in cancer patients, which provides informative implications for clinical decisions to prolong the survival of cancer patients.
28 Σεπ 2024 · Numerous clinical studies have demonstrated that the overexpression of glycolytic enzymes and glucose transporters, such as HK2 and GLUT1, is associated with poor prognosis in various types of cancer.
3 Δεκ 2013 · The objective of this review is to present the most recent research on the cancer-specific role of glycolytic enzymes including their non-glycolytic functions in order to explore the potential for therapeutic opportunities.
This review aims to clarify the glycolytic environment in tumor cells and TME cells and to enumerate potential targets, offering suggestions for additional studies and potential therapeutic uses of targeted glycolysis in cancers.
5 Δεκ 2022 · LDH-A is a cytoplasmic enzyme that is primarily involved in anaerobic and aerobic glycolytic processes, and elevated LDH-A levels are strongly correlated with worse prognosis among tumor patients (Valvona et al., 2016).
