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  1. EFSA’s Scientific Committee has identified possibilities for replacement, reduction and refinement of animal testing within EFSA’s scientific assessment activities. The Committee has also reviewed alternative methodologies that can be used to assess the safety of chemicals and can reduce animal use in toxicological research.

  2. 1 Σεπ 2023 · To this end, this report provides an overview of the current scientific developments of alternatives to animal testing. A summary of the alternative methods, including their advantages, disadvantages, future needs, and current status in food safety evaluations, has been presented in Table 1.

  3. Where a new animal test proves necessary, legislation requires that scientifically-sound approaches to the implementation of the 3Rs – reduction, refinement or replacement of animal use – are used.

  4. 1 Σεπ 2023 · If the manufacturer determines a need for animal testing, the FDA recommends considering the use of scientifically valid alternative methods to whole-animal testing which have been developed and validated by ICCVAM (U.S. FDA, 2022a).

  5. 29 Οκτ 2020 · Across the spectrum of industrial sectors, including pharmaceuticals, chemicals, personal care products, food additives and their associated regulatory agencies, there is a need to develop robust and reliable methods to reduce or replace animal testing.

  6. 24 Μαΐ 2011 · In line with the 3Rs principle, ZEBET’s main priority is to reduce the number of laboratory animals to the absolutely necessary minimum, to refine experimental procedures and housing of animals, to minimize pain and suffering and, if possible, to replace animal experiments with alternative methods.

  7. ECHA works to avoid unnecessary testing on animals and promotes alternative test methods. It acts proactively to ensure that animal testing is used only as a last resort, providing regulatory expertise and investing in worldwide platforms on chemicals data, such as IUCLID and the QSAR Toolbox.

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