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1. www.researchgate.net › publication › 362439231_Development_of_novel_ultra(PDF) Development of novel ultra-sensitive IL-11 target...

   www.researchgate.net › publication › 362439231_Development_of_novel_ultra

   31 Δεκ 2022 · An in-house antibody generation campaign identified a diverse, high affinity set of anti-interleukin-11 (IL-11) monoclonal antibodies (mAbs) to enable successful development of novel,...

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2. www.ncbi.nlm.nih.gov › pmc › articlesDevelopment of novel ultra-sensitive IL-11 target engagement...

   www.ncbi.nlm.nih.gov › pmc › articles

   2 Αυγ 2022 · An in-house antibody generation campaign identified a diverse, high affinity set of anti-interleukin-11 (IL-11) monoclonal antibodies (mAbs) to enable successful development of novel, custom ultra-sensitive target engagement assays for detection of “free” (unbound to the dosed anti-IL-11 therapeutic mAb) and “total” (free and mAb-IL-11 ...

3. onlinelibrary.wiley.com › doi › fullUnlocking longevity: How blocking IL‐11 signaling could extend...

   onlinelibrary.wiley.com › doi › full

   20 Οκτ 2024 · We highlight a recent study published in Nature which explored the role of interleukin-11 (IL-11), a pro-inflammatory cytokine, in aging. 1 The study demonstrates how inhibiting IL-11 signaling can positively impact both healthspan and lifespan in mice, suggesting a novel target for antiaging therapies with significant implications for ...

4. www.cell.com › cell-metabolism › fulltextDefying “IL-11ness” by inhibiting inflammation ... - Cell Press

   www.cell.com › cell-metabolism › fulltext

   3 Σεπ 2024 · Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity. Hee-Hoon Kim 1, 2 ∙ Vishwa Deep Dixit 1, 2, 3 vishwa.dixit@yale.edu. Download PDF. Share. More. Abstract. Organismal aging involves several hallmark pathways, including chronic inflammation and metabolic dysfunction.

5. pubmed.ncbi.nlm.nih.gov › 30268501Generation of and characterization of anti-IL-11 antibodies using...

   pubmed.ncbi.nlm.nih.gov › 30268501

   28 Οκτ 2018 · One clone of anti-IL-11 antibodies blocked IL-11-, but not IL-6-induced cell proliferation and IL-11-induced phosphorylation of STAT3 of an IL-11-dependent cell line. Moreover, we used recently established Il11-deficient mice to test the specificity of anti-IL-11 antibodies for immunohistochemistry.

6. ahfad.org › human-interleukin-11-il-11-elisa-a-comprehensive-overviewHuman Interleukin-11 (IL-11) ELISA: A Comprehensive Overview

   ahfad.org › human-interleukin-11-il-11-elisa-a-comprehensive-overview

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   The Human Interleukin-11 ELISA (Enzyme-Linked Immunosorbent Assay) is an indispensable tool for researchers aiming to measure IL-11 concentrations in various biological samples. Biological Importance of IL-11. IL-11 is secreted by fibroblasts, epithelial cells, and other cell types in response to cytokine stimulation.

7. www.biorxiv.org › content › 10Interleukin-11 plays a key role in human and mouse alcohol ... -...

   www.biorxiv.org › content › 10

   24 Αυγ 2021 · Interleukin-11 (IL-11) is a pro-fibrotic, pro-inflammatory cytokine with. increasingly recognized toxicities in parenchymal and epithelial cells. Aim: The aim of this study was to explore the prognostic value of IL-11 serum levels in. patients suffering from AH and cirrhosis of various etiology and to understand the role.