Αποτελέσματα Αναζήτησης
Timing of levels: Draw trough 30 min prior to 4th dose. Draw peak 30 min after infusion ends Once daily dosing: goal peak 35 – 60 mcg/mL; goal trough < 4 mcg/mL Conventional dosing: goal peak 25 – 35 mcg/mL for serious infections; 15 – 20 mcg/mL for UTI; goal trough < 4 – 8 mcg/mL.
Follow up trough level testing • An early trough (6-hours prior to dose) should be considered in patients demonstrating acute changes in renal function or suspicion of extended interval failure.
ADULT ANTIMICROBIAL DOSING GUIDELINES 2022 – 2023. Approved by the Antimicrobial Subcommittee and the Pharmacy and Therapeutics Committee June 2022. These dosing recommendations are meant as guidance for initial dose selection based on available literature and should not replace clinical judgement.
22 Φεβ 2023 · Trough-based protocol Trough 15-20 mg/L • In general, goal AUC/MIC ≥ 400 for S.aureus • Monitor closely with trough > 15 or AUC > 650: increased risk of nephrotoxicity
In HD, check trough before each HD session, and peak 30 minutes after each dose. Goal levels : For synergy,goal peak 3–5mg/L (3-4 if using IDSA endocarditis guidelines). Goal trough <1 mg/L
These guidelines are evidence based and reflect nationally agreed practice. They specify the recommended antimicrobial, dose, route and duration of treatment for common infections encountered in secondary care. The doses mentioned in this formulary are for adults with normal renal and hepatic function.
CRITICAL VALUES FOR THERAPEUTIC DRUG LEVELS. The concept of critical values for drug levels was originally developed by the late Daniel M. Baer, MD, and first published in the April 1982 issue of MLO. This table is an expanded version of that publication and newly revised for 2018-2019 by Steven W. Cotten PhD, DABCC, FAACC, Assistant Professor ...
