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4 Νοε 2019 · Fatigue is a common feature of the anti-nuclear antibody (ANA)-positive systemic autoimmune rheumatic diseases (SARDs), including systemic lupus erythematosus (SLE), Sjogren’s disease (SjD), systemic sclerosis (SSc), dermatomyositis, and mixed connective tissue disease [1 – 5].
16 Ιουν 2023 · CLINICAL MANIFESTATIONS. Major clinical features and organ involvement. Constitutional symptoms — Constitutional symptoms such as fatigue, fever, and weight loss are present in most patients with systemic lupus erythematosus (SLE) at some point during the course of the disease.
1 Οκτ 2014 · For many patients with SLE, fatigue disrupts normal daily functioning, decreases the ability to concentrate, and affects work, leisure, and social activities, leading to diminished quality of life, 6, 19 a high prevalence of work disability, 20, 21 and higher health care utilization. 22 At the same time, more than 80% of patients with SLE have r...
7 Αυγ 2023 · In the study cohort and the sub-cohort with autoimmune disease, ANA + was associated (P ≤ 5 × 10 –5) with 88 and 136 clinical diagnoses respectively, including lupus (OR ≥ 5.4, P ≤ 7.8 × 10 –202) and other autoimmune diseases and complications.
22 Ιουλ 2022 · Antinuclear antibody (ANA) autoantibodies, or antibodies produced by the immune system that attack the body’s own cells, are a hallmark of lupus. ANA is usually measured as 0 to 4+ or as a titer (the number of times a blood sample can be diluted and still be positive).
4 Αυγ 2023 · Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multisystemic involvement. The condition has several phenotypes, with varying clinical presentations from mild mucocutaneous manifestations to multiorgan and severe central nervous system involvement. Several immunopathogenic pathways play a role in the development of SLE.
1 Αυγ 1999 · Subsequently, it has become clear that this association reflects the fact that a subset of antinuclear antibodies can directly cause overt nephritis, one of the major causes of morbidity and mortality in SLE. The evidence for this contention has come from many sources.
